The phenotypes of mice lacking melanocortin-3 (Mcr3) and melanocortin-4 receptors (Mc4r) demonstrate that these isoforms reduce body weight through distinct and complementary mechanisms. Mc4r regulates food intake and possibly energy expenditure, whereas Mc3r influences feed efficiency and the partitioning of fuel stores into fat.
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Cummings, D., Schwartz, M. Melanocortins and body weight: a tale of two receptors. Nat Genet 26, 8–9 (2000). https://doi.org/10.1038/79223
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DOI: https://doi.org/10.1038/79223
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