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Transmission ratio distortion at the INS-IGF2 VNTR

Nature Genetics volume 22, pages 324–325 (1999)Cite this article

Transmission ratio distortion (TRD) is defined as a statistically significant departure from mendelian transmission. So far, evidence of this in humans has been limited or controversial1,2,3,4, and the few established examples involve chromosome rearrangements in lower organisms5.

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Acknowledgements

We thank W. Cookson for Busselton family DNA samples; M. Schuerenkamp for technical assistance; and the Wellcome Trust, the British Diabetic Association, the Juvenile Diabetes Foundation, the Jubilee Fund of the Austrian National Bank, the Bundesministerium für Forschung, Bildung und Technologie and the Italian Telethon for financial support.

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Authors and Affiliations

  1. Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 2XY, UK

    Iain A. Eaves, Simon T. Bennett, Amanda J. Wilson & John A. Todd

  2. Institut für Rechtsmedizin, Universität Münster, Von-Esmarch-Str. 62, Münster, D-48129, Germany

    Peter Forster & Bernd Brinkmann

  3. Institut für Diabetesforschung and Academic Teaching Hospital München-Schwabing, Munich, Germany

    Karin M. Ferber & Anette-G. Ziegler

  4. Department of Medicine, University of Chicago, Chicago, USA

    David Ehrmann

  5. Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Headington, OX3 7BN, Oxford, UK

    Sumit Bhattacharyya

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  1. Iain A. Eaves
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Correspondence to John A. Todd.

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Eaves, I., Bennett, S., Forster, P. et al. Transmission ratio distortion at the INS-IGF2 VNTR. Nat Genet 22, 324–325 (1999). https://doi.org/10.1038/11890

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