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Distinct genetic loci control development of benign and malignant skin tumours in mice

Nature Genetics volume 10, pages 424–429 (1995)Cite this article

Abstract

Genetic susceptibility to chemically induced skin cancer in mice is controlled by multiple unlinked genetic loci. Mus spretus mice have dominant resistance genes which confer resistance to interspecific F1 hybrids with susceptible Mus musculus strains. We have mapped three major resistance loci using a combination of Mapmaker/QTL analysis and multiple regression analysis to mouse chromosomes 5 and 7. At least two independent loci on chromosome 7 exert their effects primarily during benign tumour development and have very little influence on tumour progression. On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control.

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Authors and Affiliations

  1. CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow and Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK

    Hiroki Nagase, Sheila Bryson, Frances Fee & Allan Balmain

  2. Nuffield Department of Surgery, The Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Headington, Oxford, OX3 7BN, UK

    Heather Cordell

  3. Fred Hutchinson Cancer Research Center, C1-015, 1124 Columbia Street, Seattle, Washington, 98104, USA

    Christopher J. Kemp

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  1. Hiroki Nagase
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  4. Christopher J. Kemp
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  6. Allan Balmain
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Nagase, H., Bryson, S., Cordell, H. et al. Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat Genet 10, 424–429 (1995). https://doi.org/10.1038/ng0895-424

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