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Cooperative tumorigenic effects of germline mutations in Rb and p53

Nature Genetics volume 7, pages 480484 (1994) | Download Citation

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Abstract

The tumour suppressor genes Rb and p53 are mutated in several types of human cancer, and many tumour types carry mutations in both genes. To study how these genes normally function, we and others have created mouse strains with Rb and p53 mutations. Here we describe the phenotypic effects of combined germline mutations in these two tumour suppressor genes. Mice mutant for both genes have reduced viability and exhibit novel pathology including pinealoblastomas, islet cell tumours, bronchial epithelial hyperplasia and retinal dysplasia. These data indicate that mutations in Rb and p53 can cooperate in the transformation of certain cell types in the mouse.

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Affiliations

  1. Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

    • Bart O. Williams
    • , Lee Remington
    •  & Tyler Jacks
  2. Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin 53792, USA

    • Daniel M. Albert
  3. Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA

    • Shizuo Mukai
  4. Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, Boston, Massachusetts 02111, USA

    • Roderick T. Bronson

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DOI

https://doi.org/10.1038/ng0894-480

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