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Chromosomal distribution of 320 genes from a brain cDNA library

Nature Genetics volume 4, pages 381–386 (1993)Cite this article

Abstract

We have determined the chromosomal assignment of 320 brain expressed genes by studying the segregation of polymerase chain reaction (PCR) products in human rodent somatic cell hybrids and by genetically mapping polymorphic cDNAs using the CEPH (Centre d'Etude du Polymophisme Humaine) reference pedigrees and database. These mapped genes can function as markers on the physical map of the human genome, as well as serve as candidate disease gene loci. Distribution of these genes to the human chromosomes correlates well with the GC content of the chromosomes. However, the distribution of these genes does not correlate well with the cytogenetic length of each chromosome.

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Authors and Affiliations

  1. Laboratory of Biochemical Genetics, National Institute of Mental Health, Neuroscience Center at St. Elizabeths, Washington, DC, 20032, USA

    Mihael H. Polymeropoulos, Hong Xiao & Carl R. Merril

  2. Health Sciences Center, University of Colorado, 4200 East 9th Avenue, Denver, Colorado, 80262, USA

    James M. Sikela

  3. The Institute for Genomic Research, 932 Clopper Road, Gaithersburg, Maryland, 20878, USA

    Mark Adams & J. Craig Venter

Authors
  1. Mihael H. Polymeropoulos
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  2. Hong Xiao
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  3. James M. Sikela
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  4. Mark Adams
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  5. J. Craig Venter
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  6. Carl R. Merril
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Polymeropoulos, M., Xiao, H., Sikela, J. et al. Chromosomal distribution of 320 genes from a brain cDNA library. Nat Genet 4, 381–386 (1993). https://doi.org/10.1038/ng0893-381

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