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Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3

Nature Genetics volume 1, pages 348–353 (1992)Cite this article

Abstract

The sequences of three cosmids (90 kilobases) from the Huntington's disease region in chromosome 4p16.3 have been determined. A 30,837 base overlap of DNA sequenced from two individuals was found to contain 72 DNA sequence polymorphisms, an average of 2.3 polymorphisms per kilobase (kb). The assembled 58 kb contig contains 62 Alu repeats, and eleven predicted exons representing at least three expressed genes that encode previously unidentified proteins. Each of these genes is associated with a CpG island. The structure of one of the new genes, hda1–1, has been determined by characterizing cDNAs from a placental library. This gene is expressed in a variety of tissues and may encode a novel housekeeping gene.

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Author information

Authors and Affiliations

  1. Section of Receptor Biochemistry and Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA

    W.R. McCombie, A. Martin-Gallardo, J.D. Gocayne, M. FitzGerald, M. Dubnick, J.M. Kelley, L.I. Liu, S. Wallace, S. Trapp, A. R. Kerlavage, C. Fields & J.C. Venter

  2. Departments of Internal Medicine and Human Genetics and The Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, 48109, USA

    L. Castilla, D. Tagle & F. S. Collins

  3. Molecular Neurogenetics Laboratory, Massachusetts General Hospital, and Department of Genetics, Harvard University, MGH East, Building 149, 13th Street, Charlestown, Massachusetts, 02129, USA

    W.L. Whaley, S. Cheng & J. Gusella

  4. Department of Genome Analysis, Imperial Cancer Research Fund Laboratories, London, WC2A 3PX, England

    A.-M. Frischauf & H. Lehrach

  5. Deutsches Krebsforschungszentrum, D-69, Heidelberg, Germany

    A. Poustka

Authors
  1. W.R. McCombie
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  2. A. Martin-Gallardo
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McCombie, W., Martin-Gallardo, A., Gocayne, J. et al. Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3. Nat Genet 1, 348–353 (1992). https://doi.org/10.1038/ng0892-348

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