A new study reports the first mouse model for ATR-mutated Seckel syndrome. The mice show phenotypes recapitulating the human disorder and provide insights into how reduced ATR function affects normal embryonic development by increasing replicative stress, ultimately resulting in an accelerated aging phenotype postnatally.
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O'Driscoll, M. Life can be stressful without ATR. Nat Genet 41, 866–868 (2009). https://doi.org/10.1038/ng0809-866
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DOI: https://doi.org/10.1038/ng0809-866
