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One PRDM is not enough for germ cell development

Developmentally regulated expression of the transcriptional repressor Prdm1 (Blimp1) in the early mammalian embryo controls global epigenetic changes required for specification of primordial germ cells. A new study demonstrates that a close family member, Prdm14, similarly activated in response to Bmp and Smad signals, also has an essential role during establishment of the germ cell lineage.

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Figure 1: Master regulators of germ cell fate.

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Bikoff, E., Robertson, E. One PRDM is not enough for germ cell development. Nat Genet 40, 934–935 (2008). https://doi.org/10.1038/ng0808-934

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