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H19 in the pouch

The linked maternally expressed H19 and paternally expressed Igf2 genes use a CTCF-dependent DNA methylation–sensitive insulator to govern their allele-specific imprinting patterns. Contrary to expectations, a new study shows that the noncoding H19 RNA has a marsupial ortholog and that key features of the locus are similar, indicating that the imprinting regulation of this locus is conserved among therian mammals.

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Figure 1: Conserved H19-associated features in mouse and wallaby.

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Bartolomei, M., Vigneau, S. & O'Neill, M. H19 in the pouch. Nat Genet 40, 932–933 (2008). https://doi.org/10.1038/ng0808-932

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