Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A step forward for restless legs syndrome

Two genome-wide association studies report three loci predisposing to restless legs syndrome, a common sleep disorder also associated with periodic limb movements during sleep. The identified variants account for a large portion of population-attributable risk in individuals of European ancestry and may preferentially affect various symptoms of the disorder.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Allen, R.P. Am. J. Med. 120, S13 –S21 (2007).

    Article  Google Scholar 

  2. Kushida, C.A. Am. J. Med. 120, S4–S12 (2007).

    Article  Google Scholar 

  3. Winkelmann, J. et al. Nat. Genet. 39, 1000–1006 (2007).

    Article  CAS  Google Scholar 

  4. Stefansson, H. et al. N. Eng. J. Med. published online 18 July 2007 (doi:10.1056/NEJMoa072743).

    Article  CAS  Google Scholar 

  5. Hening, W.A. Am. J. Med. 120, S22–S27 (2007).

    Article  Google Scholar 

  6. Godau, J. et al. Mov. Disord. 22, 187–192 (2007).

    Article  Google Scholar 

  7. Lavoie, S. & Drew, T. J. Neurophysiol. 88, 1791–1814 (2002).

    Article  Google Scholar 

  8. Bucher, S.F. et al. Ann. Neurol. 41, 639–645 (1997).

    Article  CAS  Google Scholar 

  9. Haba-Rubio, J. et al. J. Neurol. Neurosurg. Psychiatry 76, 1009–1010 (2005).

    Article  CAS  Google Scholar 

  10. Mizuhara, E. et al. J. Biol. Chem. 280, 3645–3655 (2005).

    Article  CAS  Google Scholar 

  11. Cheng, L. et al., Nat. Neurosci. 8, 1510–1515 (2005).

    Article  CAS  Google Scholar 

  12. Tan, E.K. et al. Mov. Disord. 16, 577–579 (2001).

    Article  CAS  Google Scholar 

  13. Mizuno, S. et al. Psychiatry Clin. Neurosci. 59, 461–465 (2005).

    Article  Google Scholar 

  14. ENCODE Project Consortium. Nature 447, 799–816 (2007).

  15. Kikuta, H. et al. Genome Res. 17, 545–555 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mignot, E. A step forward for restless legs syndrome. Nat Genet 39, 938–939 (2007). https://doi.org/10.1038/ng0807-938

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0807-938

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing