Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Target mimics modulate miRNAs

A 23-nucleotide sequence conserved in species from rice to Arabidopsis thaliana in a family of noncoding RNAs resembles a cleavable miRNA target site—but not exactly. A new study demonstrates that the site is not cleaved and instead negatively regulates miRNA activity through mimicry.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Possible models of how the induction of the Pi deprivation response in plants is regulated by an miRNA and its target mimic.

References

  1. Franco-Zorrilla, J.M. et al. Nat. Genet. 39, 1033–1037 (2007).

    Article  CAS  Google Scholar 

  2. Raghothama, K.G. Annu. Rev. Plant Physiol. Plant Mol. Biol. 50, 665–693 (1999).

    Article  CAS  Google Scholar 

  3. Abel, S., Ticconi, C.A. & Delatorre, C.A. Physiol. Plant. 115, 1–8 (2002).

    Article  CAS  Google Scholar 

  4. Fujii, H. et al. Curr. Biol. 15, 2038–2043 (2005).

    Article  CAS  Google Scholar 

  5. Chiou, T.J. et al. Plant Cell 18, 412–421 (2006).

    Article  CAS  Google Scholar 

  6. Aung, K. et al. Plant Physiol. 141, 1000–1011 (2006).

    Article  CAS  Google Scholar 

  7. Bari, R. et al. Plant Physiol. 141, 988–999 (2006).

    Article  CAS  Google Scholar 

  8. Liu, C., Muchhal, U.S. & Raghothama, K.G. Plant Mol. Biol. 33, 867–874 (1997).

    Article  CAS  Google Scholar 

  9. Burleigh, S.H. & Harrison, M.J. Plant Mol. Biol. 34, 199–208 (1997).

    Article  CAS  Google Scholar 

  10. Shin, H. et al. Plant J. 45, 712–726 (2006).

    Article  CAS  Google Scholar 

  11. Axtell, M.J. et al. Cell 127, 565–577 (2006).

    Article  CAS  Google Scholar 

  12. Mallory, A.C. & Vaucheret, H. Nat. Genet. 38, S31–S36 (2006).

    Article  CAS  Google Scholar 

  13. Chiou, T.J. Plant Cell Environ. 30, 323–332 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chitwood, D., Timmermans, M. Target mimics modulate miRNAs. Nat Genet 39, 935–936 (2007). https://doi.org/10.1038/ng0807-935

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0807-935

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing