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Target mimics modulate miRNAs

A 23-nucleotide sequence conserved in species from rice to Arabidopsis thaliana in a family of noncoding RNAs resembles a cleavable miRNA target site—but not exactly. A new study demonstrates that the site is not cleaved and instead negatively regulates miRNA activity through mimicry.

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Figure 1: Possible models of how the induction of the Pi deprivation response in plants is regulated by an miRNA and its target mimic.


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Chitwood, D., Timmermans, M. Target mimics modulate miRNAs. Nat Genet 39, 935–936 (2007).

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