Closing in on complex traits

Article metrics

A new study involving a population of 1,904 heterogeneous mice bred for 50 generations, phenotyped for 101 traits and genotyped for 13,459 SNPs, presents the most comprehensive analysis thus far of complex traits in mice. The work represents a landmark resource for the mouse genetics community and offers important insights into the genetic architecture of complex traits.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Heterogeneous stock mice (illustrated in this picture) helped Valdar et al. detect 843 QTLs.

References

  1. 1

    Valdar, W. et al. Nat. Genet. 38, 879–887 (2006).

  2. 2

    Darvasi, A. & Soller, M. Genetics 141, 1199–1207 (1995).

  3. 3

    Couzin, J. Science 309, 81 (2005).

  4. 4

    Weiss, K.M. & Terwilliger, J.D. Nat. Genet. 26, 151–157 (2000).

  5. 5

    Flint, J., Valdar, W., Shifman, S. & Mott, R. Nat. Rev. Genet. 6, 271–286 (2005).

  6. 6

    Austin, C.P. et al. Nat. Genet. 36, 921–924 (2004).

  7. 7

    Auwerx, J. et al. Nat. Genet. 36, 925–927 (2004).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Darvasi, A. Closing in on complex traits. Nat Genet 38, 861–862 (2006) doi:10.1038/ng0806-861

Download citation

Further reading