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Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin

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We thank all volunteers for their cooperation in this study; T. Kato for freely sharing with us all of his raw data; J. Steele and E. Meyer for data management; S. Weber, S. Pottgiesser, K. Prell, V. Heidmann, M. Deschner and S. Kovalenko for sample collection and data documentation; and N. Cox for critical review of the manuscript. This study was supported by the Fund for Scientific Research Flanders, the Interuniversity Attraction Poles of the Belgian Federal Science Policy, a Concerted Research Project by the University of Antwerp, and the NIMH Intramural Research Program. The collection of samples from the NIMH Genetics Initiative families was supported by grants from the NIMH Extramural Research program. NIMH DNA samples were prepared and distributed by Rutgers University under a contract from the NIMH. The collection of samples from the families in Bulgaria was funded by the Janssen Research Foundation, Belgium. The laboratory work and recruitment of affected individuals in the U.K. was funded by the Wellcome Trust. This work was also supported by the Polish State Committee for Scientific Research, the National Genomic Network of the German Ministry of Education and Research, the Deutsche Forschungsgemeinschaft and the Alfried Krupp von Bohlen und Halbach-Stiftung. A.V.D.B. holds a predoctoral position with the Institute for the Promotion of Innovation by Science and Technology in Flanders. T.G.S. is the recipient of a Young Investigators Award from the National Alliance for Research on Schizophrenia and Depression. P.M.C. is the recipient of a 2004 Annual Stipend for Young Scientists from the Foundation for Polish Science.

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Correspondence to Sven Cichon.

Supplementary information

Supplementary Table 1

Genotype and allele frequencies of the XBP1 −116C→G polymorphism in case-control samples from the UK, Germany and Poland.

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