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Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin

Nature Genetics volume 36, pages 783–784 (2004)Cite this article

To the editor:

Kakiuchi and colleagues1 reported that variation in the gene XBP1 contributes to susceptibility to bipolar affective disorder (BPAD). They identified a functional promoter polymorphism of XBP1 (−116C→ G) and reported association of the G allele with BPAD in 197 Japanese probands and 451 Japanese controls and in 88 trios from the National Institutes of Health (NIMH) Genetics Initiative collection of (mainly) European American families identified through a sibling pair with BPAD. They also reported evidence that constructs carrying the G allele resulted in an in vitro cellular phenotype that was reversed by valproate, an effective treatment for BPAD.

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Acknowledgements

We thank all volunteers for their cooperation in this study; T. Kato for freely sharing with us all of his raw data; J. Steele and E. Meyer for data management; S. Weber, S. Pottgiesser, K. Prell, V. Heidmann, M. Deschner and S. Kovalenko for sample collection and data documentation; and N. Cox for critical review of the manuscript. This study was supported by the Fund for Scientific Research Flanders, the Interuniversity Attraction Poles of the Belgian Federal Science Policy, a Concerted Research Project by the University of Antwerp, and the NIMH Intramural Research Program. The collection of samples from the NIMH Genetics Initiative families was supported by grants from the NIMH Extramural Research program. NIMH DNA samples were prepared and distributed by Rutgers University under a contract from the NIMH. The collection of samples from the families in Bulgaria was funded by the Janssen Research Foundation, Belgium. The laboratory work and recruitment of affected individuals in the U.K. was funded by the Wellcome Trust. This work was also supported by the Polish State Committee for Scientific Research, the National Genomic Network of the German Ministry of Education and Research, the Deutsche Forschungsgemeinschaft and the Alfried Krupp von Bohlen und Halbach-Stiftung. A.V.D.B. holds a predoctoral position with the Institute for the Promotion of Innovation by Science and Technology in Flanders. T.G.S. is the recipient of a Young Investigators Award from the National Alliance for Research on Schizophrenia and Depression. P.M.C. is the recipient of a 2004 Annual Stipend for Young Scientists from the Foundation for Polish Science.

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Authors and Affiliations

  1. Life & Brain Center, University of Bonn, Bonn, Germany

    Sven Cichon & Markus M Nöthen

  2. Department of Medical Genetics, University of Antwerp, Antwerp, Belgium

    Sven Cichon, Ann Van Den Bogaert & Markus M Nöthen

  3. Department of Health and Human Services, Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA

    Silvia Buervenich, Nirmala Akula & Francis J McMahon

  4. Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine Heath Park, Cardiff, UK

    George Kirov, Albena Dimitrova, Elaine Green, Marian Hamshere, Ian Jones, Michael C O'Donovan, Michael J Owen & Nick Craddock

  5. Institute of Human Genetics, University of Bonn, Bonn, Germany

    Johannes Schumacher & Peter Propping

  6. Institute of Epidemiology, GSF-National Research Center for Environment and Health, Neuherberg, Germany

    Norman Klopp & Thomas Illig

  7. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany

    Tim Becker

  8. Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany

    Stephanie Ohlraun, Thomas G Schulze & Marcella Rietschel

  9. Department of Psychiatry, University of Bonn, Bonn, Germany

    Stephanie Ohlraun, Thomas G Schulze, Monja Tullius, Magdalena M Gross, Wolfgang Maier & Marcella Rietschel

  10. Department of Medical Genetics, Medical University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK

    Lisa Jones

  11. Department of Psychiatry, Medical University Sofia, Sofia, Bulgaria

    Stefan Krastev

  12. Department of Psychological Medicine, Biostatistics Bioinformatics Unit, University of Wales College of Medicine Heath Park, Cardiff, UK

    Ivan Nikolov

  13. Department of Adult Psychiatry, University of Medical Sciences Poznan, Poznan, Poland

    Piotr M Czerski, Anna Leszczynska-Rodziewicz, Pawel Kapelski & Joanna Hauser

  14. Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Wade Berrettini

  15. University of California, Irvine, California, USA

    William Byerley

  16. Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA

    William Coryell

  17. Department of Psychiatry, University of Chicago, Chicago, Illinois, USA

    Elliot S Gershon

  18. Department of Psychiatry, University of California, San Diego, California, USA

    John R Kelsoe

  19. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA

    Melvin G McInnis

  20. Department of Health and Human Services, Laboratory of Clinical Science, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA

    Dennis L Murphy

  21. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA

    John I Nurnberger Jr

  22. Department of Psychiatry, Washington University, St. Louis, Missouri, USA

    Theodore Reich

  23. Department of Psychiatry, Rush University Medical Center, Chicago, Illinois, USA

    William Scheftner

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  42. Nick Craddock
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Corresponding author

Correspondence to Sven Cichon.

Supplementary information

Supplementary Table 1

Genotype and allele frequencies of the XBP1 −116C→G polymorphism in case-control samples from the UK, Germany and Poland.

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Cichon, S., Buervenich, S., Kirov, G. et al. Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nat Genet 36, 783–784 (2004). https://doi.org/10.1038/ng0804-783

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