Tailoring vectors through DNA shuffling

Rational vector design is pivotal for successful human gene therapy and the application of high-throughput methods may provide a means for the efficient realization of vectors with desired properties. A method involving DNA shuffling represents a powerful new paradigm in this regard.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Orkin, S.H. & Motulski, A.G. http://www.nih.gov/news/panelrep.html

  2. 2

    Soong, N.W. et al. Nature Genet. 25, 436– 439 (2000).

  3. 3

    Cavazzana-Calvo, M. Science 288, 669–672 ( 2000).

  4. 4

    Anderson, W.F. Science 288, 627–629 ( 2000).

  5. 5

    Barry M.A., Dower, W.J. & Johnston, S.A. Nature Med. 2, 299– 305 (1996).

  6. 6

    Pasqualini, R. & Ruoslahti, E. Nature 380, 364–366 (1996).

  7. 7

    Krasnykh, V.N., Douglas, J.T. & van Beusechem, V.W. Mol. Ther. 1, 391– 405 (2000).

  8. 8

    Adachi, Y. et al. Cancer Res. (in press).

  9. 9

    Rancourt, C. et al. Clin. Cancer Res. 4, 2455– 2461 (1998).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Curiel, D. Tailoring vectors through DNA shuffling. Nat Genet 25, 366–367 (2000). https://doi.org/10.1038/78023

Download citation