Rational vector design is pivotal for successful human gene therapy and the application of high-throughput methods may provide a means for the efficient realization of vectors with desired properties. A method involving DNA shuffling represents a powerful new paradigm in this regard.
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Curiel, D. Tailoring vectors through DNA shuffling. Nat Genet 25, 366–367 (2000). https://doi.org/10.1038/78023
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DOI: https://doi.org/10.1038/78023