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Accelerated telomere shortening in ataxia telangiectasia

Nature Genetics volume 13, pages 350–353 (1996)Cite this article

Abstract

Ataxia telangiectasia (AT) is characterized by neurological deterioration, immunodeficiency, spontaneous chromosomal instability, hypersensitivity to ionizing radiation, predisposition to cancer, particularly T cell leukaemia and lymphoma, and premature ageing1. The most commonly observed defect affecting telomeres in humans is telomeric fusions, particularly in T lymphocytes in AT patients2–4. Rarely, some tumour cells5–11, like senescent cells12, have dicentric chromosomes that may arise as a result of telomeric sequence loss. We show that the AT mutation in the homozygous state confers a predisposition to accelerated telomere shortening with increasing age in peripheral blood lymphocytes (PBLs), which may be linked to premature senescence. We also show that telomeric fusions are associated with large (>90%) pre-leukaemic translocation clones in T cells. We propose that these fusions may result from a compound effect of accelerated telomere shortening, together with a growth advantage of cells in large clones which leads to further telomere loss. Fusions are not observed in leukaemic cells in these patients. There is no evidence that either accelerated telomere loss per se or telomeric fusions are important in tumourigenesis. Telomerase is present in both normal and AT lymphocytes and so neither telomere shortening nor telomeric fusions can be explained by the absence of telomerase.

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Authors and Affiliations

  1. CRC Institute for Cancer Studies, The Medical School University of Birmingham, Birmingham, B15 2TT, UK

    Judith A. Metcalfe, Julian Parkhill, Louise Campbell, Michael Stacey, Paul Biggs, Philip J. Byrd & A. Malcolm R. Taylor

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  1. Judith A. Metcalfe
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  2. Julian Parkhill
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  3. Louise Campbell
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  7. A. Malcolm R. Taylor
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Correspondence to A. Malcolm R. Taylor.

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Metcalfe, J., Parkhill, J., Campbell, L. et al. Accelerated telomere shortening in ataxia telangiectasia. Nat Genet 13, 350–353 (1996). https://doi.org/10.1038/ng0796-350

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