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How many genes in the human genome?

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References

  1. 1

    Collins, F. & Galas, D. Science 262, 43–46 (1993).

    CAS  Article  Google Scholar 

  2. 2

    Watson, J.D. In The Code of Codes (eds Kevles, D.J. & Hood, L.) 164–173 (Harvard University Press, Cambridge, 1992).

    Google Scholar 

  3. 3

    U.S. Department of Health and Human Services, U.S. Department of Energy. Understanding Our Genetic Inheritance, The U.S. Human Genome Project: The First Five Years, FY 1991–1995. DOE/ER-0452P (1990).

  4. 4

    Gilbert, W. In The Code of Codes (eds Kevles, D.J. & Hood, L.) 83–97 (Harvard University Press, Cambridge, 992).

  5. 5

    McCombie, W.R. et al. Nature Genet. 1, 348–353 (1992).

    CAS  Article  Google Scholar 

  6. 6

    Martin-Gallardo, A. et al. Nature Genet. 1, 34–39 (1992).

    CAS  Article  Google Scholar 

  7. 7

    Xu, G. et al. Cell 62, 599–608 (1990).

    CAS  Article  Google Scholar 

  8. 8

    Marchuk, D.A. Genomics 11, 931–940 (1991).

    CAS  Article  Google Scholar 

  9. 9

    Wagner, R., Maguire, M. & Staliings, R. Chromosomes: A Synthesis (Wiley, New York, 1993).

    Google Scholar 

  10. 10

    Lewin, B. Genes IV (Oxford University Press, 1990).

  11. 11

    Antequera, F. & Bird, A. Proc. natn. Acad. Sci. U.S.A. 90, 11995–11999 (1993).

    CAS  Article  Google Scholar 

  12. 12

    Adams, M.D. et al. Science 252, 1651–1656 (1991).

    CAS  Article  Google Scholar 

  13. 13

    Wateraton, R. et al. Nature Genet. 1, 114–123 (1992).

    Article  Google Scholar 

  14. 14

    Pearson, W. & Lipman, J. Proc. natn. Acad. Sci. U.S.A. 85, 2444–2448 (1988).

    CAS  Article  Google Scholar 

  15. 15

    Brutlag, D.L. et al. Computers and Chemistry 17, 203–207 (1993).

    CAS  Article  Google Scholar 

  16. 16

    Lee, R.C., Feinbaum, R.L. & Ambros, V. Cell 75, 843–854 (1993).

    CAS  Article  Google Scholar 

  17. 17

    Spieth, J. et al. Cell 73, 521–532 (1993).

    CAS  Article  Google Scholar 

  18. 18

    Alphonso, A. et al. J. molec. Biol. (in the press).

Download references

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Fields, C., Adams, M., White, O. et al. How many genes in the human genome?. Nat Genet 7, 345–346 (1994). https://doi.org/10.1038/ng0794-345

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