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Limits of sequence and functional conservation

Sequence conservation of noncoding DNA across species can indicate functional conservation. However, a new study demonstrates notable differences between human and mouse stem cell regulatory networks, suggesting caution in generalizing from sequence to functional conservation.

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Figure 1: Conservation and rewiring of regulatory elements between human and mouse genomes.


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Correspondence to Len A Pennacchio or Axel Visel.

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Pennacchio, L., Visel, A. Limits of sequence and functional conservation. Nat Genet 42, 557–558 (2010).

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