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Tumors line up for a letdown

MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. A new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.

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Figure 1: Lin-28 is associated with disease progression.


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Mendell, J. Tumors line up for a letdown. Nat Genet 41, 768–769 (2009).

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