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Tumors line up for a letdown

Nature Genetics volume 41, pages 768–769 (2009)Cite this article

MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. A new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.

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Figure 1: Lin-28 is associated with disease progression.

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Authors and Affiliations

  1. Joshua T. Mendell is at the McKusick-Nathans Institute of Genetic Medicine and Departments of Pediatrics and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. jmendell@jhmi.edu,

    Joshua T Mendell

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  1. Joshua T Mendell
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Mendell, J. Tumors line up for a letdown. Nat Genet 41, 768–769 (2009). https://doi.org/10.1038/ng0709-768

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