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A new identity for the elusive intestinal stem cell

Nature Genetics volume 40, pages 818–819 (2008)Cite this article

The tremendous regenerative power of the intestinal epithelium has attracted considerable attention to the crypt as a model for adult stem cell biology. A new study now identifies the Polycomb group protein Bmi1 as a specific marker of intestinal stem cells in vivo.

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Figure 1: Section of a mouse small intestine stained with hematoxylin and eosin.

References

  1. Sangiorgi, E. & Capecchi, M. Nat. Genet. 40, 915–920 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Potten, C.S., Booth, C. & Pritchard, D.M. Int. J. Exp. Pathol. 78, 219–243 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Potten, C.S., Owen, G. & Booth, D. J. Cell Sci. 115, 2381–2388 (2002).

    CAS  PubMed  Google Scholar 

  4. Taylor, G., Lehrer, M.S., Jensen, P.J., Sun, T.T. & Lavker, R.M. Cell 102, 451–461 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Shinin, V., Gayraud-Morel, B., Gomes, D. & Tajbakhsh, S. Nat. Cell Biol. 8, 677–687 (2006).

    Article  CAS  PubMed  Google Scholar 

  6. Bjerknes, M. & Cheng, H. Methods Enzymol. 419, 337–383 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Bjerknes, M. & Cheng, H. Gastroenterology 116, 7–14 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. Barker, N. et al. Nature 449, 1003–1007 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Valk-Lingbeek, M.E., Bruggeman, S.W. & van Louizen, M. Cell 118, 409–418 (2004).

    Article  CAS  PubMed  Google Scholar 

  10. Fuchs, E. J. Cell Biol. 180, 273–284 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Kiel, M.J. & Morrison, S.J. Nat. Rev. Immunol. 8, 290–301 (2008).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Eduard Batlle is in the Institució Catalana de Recerca Estudis Avançats (ICREA) and Oncology Programme at the Institute for Research in Biomedicine (IRB), Barcelona 08028, Spain. eduard.batlle@irbbarcelona.org,

    Eduard Batlle

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  1. Eduard Batlle
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Batlle, E. A new identity for the elusive intestinal stem cell. Nat Genet 40, 818–819 (2008). https://doi.org/10.1038/ng0708-818

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  • DOI: https://doi.org/10.1038/ng0708-818

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