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PGC-1α at the crossroads of type 2 diabetes

Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated change in gene expression.

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Figure 1: PGC-1α induces expression of mitochondrial respiratory genes and of GLUT4.

Katie Ris


  1. Holloszy, J.O. J. Biol. Chem. 242, 2278–2282 (1967).

    CAS  PubMed  Google Scholar 

  2. Hood, D.A. J. Appl. Physiol. 90, 1137–1157 (2001).

    Article  CAS  Google Scholar 

  3. Regensteiner, J.G. et al. J. Appl. Physiol. 85, 310–317 (1998).

    Article  CAS  Google Scholar 

  4. Kelley, D.E., He, J., Menshikova, E.V. & Ritov, V.B. Diabetes 51, 2944–2950 (2002).

    Article  CAS  Google Scholar 

  5. Puigserver, P. & Spiegelman, B.M. Endocr. Rev. 24, 78–90 (2003).

    Article  CAS  Google Scholar 

  6. Mootha, V.K. et al. Nat. Genet. 34, 267–273 (2003).

    Article  CAS  Google Scholar 

  7. Hardie, D.G., Carling, D. & Carlson, M. Annu. Rev. Biochem. 67, 821–855 (1998).

    Article  CAS  Google Scholar 

  8. Sakamoto, K. & Goodyear, L.J. J. Appl. Physiol. 93, 369–383 (2002).

    Article  CAS  Google Scholar 

  9. Handschin, C., Rhee, J., Lin, J., Tarr, P.T. & Spiegelman, B.M. Proc. Natl. Acad. Sci. USA (in the press).

  10. Wu, H. et al. Science 296, 349–352 (2002).

    Article  CAS  Google Scholar 

  11. Obici, S. et al. J. Clin. Invest. 109, 1599–1605 (2002).

    Article  CAS  Google Scholar 

  12. Koubova, J. & Guarente, L. Genes Dev. 17, 313–321 (2003).

    Article  CAS  Google Scholar 

  13. Neel, J.V. Am. J. Hum. Genet. 14, 353–362 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Patti, M.E. et al. Proc. Natl. Acad. Sci. USA (in the press).

  15. Petersen, K.F. et al. Science 300, 1140–1142 (2003).

    Article  CAS  Google Scholar 

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Attie, A., Kendziorski, C. PGC-1α at the crossroads of type 2 diabetes. Nat Genet 34, 244–245 (2003).

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