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PGC-1α at the crossroads of type 2 diabetes

Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated change in gene expression.

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Figure 1: PGC-1α induces expression of mitochondrial respiratory genes and of GLUT4.

Katie Ris

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Attie, A., Kendziorski, C. PGC-1α at the crossroads of type 2 diabetes. Nat Genet 34, 244–245 (2003). https://doi.org/10.1038/ng0703-244

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