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A putative gene causes variability in lifespan among genotypically identical mice

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Figure 1: Mapping a locus conferring variability on organismal longevity.
Figure 2: Phenotypic consequences of allelic variation at the putative locus conferring longevity variability.


  1. Jazwinski, S.M. Science 273, 54–59 (1996).

    Article  CAS  Google Scholar 

  2. Martin, G.M., Austad, S.N. & Johnson, T.E. Nature Genet. 13, 25–34 (1996).

    Article  CAS  Google Scholar 

  3. de Haan, G. & Van Zant, G. J. Exp. Med. 186, 529–536 (1997).

    Article  CAS  Google Scholar 

  4. Gelman, R., Watson, A., Bronson, R. & Yunis, E. Genetics 118, 693–704 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Manley, K.F. Mamm. Genome 4,303–313 (1993).

    Article  Google Scholar 

  6. Russel, E.S. in Biology of the Laboratory Mouse, (ed Green, E.L.) 511–519, (McGraw-Hill, New York, 1966).

    Google Scholar 

  7. Harley, C.B., Futcher, A.B. & Greider, C.W. Nature 345, 458–460 (1990).

    Article  CAS  Google Scholar 

  8. Blasco, M.A., Rizen, M., Greider, C.W. & Hanahan, D. Nature Genet. 12, 200–204 (1996).

    Article  CAS  Google Scholar 

  9. Zijlmans, J.M.J.M. et al. Proc. Natl. Acad. Sci. USA 94, 7423–7428 (1997).

    Article  CAS  Google Scholar 

  10. Bodnar, A.G. Science 279, 349–352 (1998).

    Article  CAS  Google Scholar 

  11. Blasco, M.A. et al. Cell 91, 25–34 (1997).

    Article  CAS  Google Scholar 

  12. Berg, K. Ciba Foundation Symposium 130, 14–33 (John Wiley & Sons, Chichester, UK, 1987).

    CAS  PubMed  Google Scholar 

  13. McClearn, G.E. Exp. Gerontol. 12, 49–54 (1997).

    Article  Google Scholar 

Download references


This work was supported by the Lucille P. Markey Cancer Center, the University of Kentucky Hospital and the Department of Internal Medicine. The original lifespan studies were carried out with support of NIH grant AG02329.

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Correspondence to Gary Van Zant.

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de Haan, G., Gelman, R., Watson, A. et al. A putative gene causes variability in lifespan among genotypically identical mice. Nat Genet 19, 114–116 (1998).

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