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Relics of selection in the mycobacterial genome

A new study reports the whole-genome sequences of 21 Mycobacterium tuberculosis complex strains, selected to represent geographically diverse isolates. Comparative genomic analyses identify surprising conservation of epitopes recognized by human T cells.

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Figure 1: The population dynamics of Mycobacterium tuberculosis are influenced by immune-related selection during growth within a host.

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Correspondence to Eric J Rubin.

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Sassetti, C., Rubin, E. Relics of selection in the mycobacterial genome. Nat Genet 42, 476–478 (2010). https://doi.org/10.1038/ng0610-476

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