Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Narcolepsy and the T-cell receptor

The etiology of the sleep disorder narcolepsy has not been firmly established, although an autoimmune pathogenesis has been proposed and is supported by a strong genetic association with the HLA. A new genome-wide association study provides further support for the autoimmune basis of narcolepsy by uncovering a robust association at the T-cell receptor alpha locus.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Sketch illustrating typical clinical features of narcolepsy: acute onset sleep in the setting of multiple environmental stimuli.


  1. Hallmayer, J. et al. Nat. Genet. 41, 708–711 (2009).

    Article  CAS  Google Scholar 

  2. Langdon, N., Welsh, K.I., van Dam, M., Vaughan, R.W. & Parkes, D. Lancet 324, 1178–1180 (1984).

    Article  Google Scholar 

  3. Matsuki, K. et al. Lancet 339, 1052 (1992).

    Article  CAS  Google Scholar 

  4. Fernando, M.M. et al. PLoS Genet. 4, e1000024 (2008).

    Article  Google Scholar 

  5. Harvey, R.C. & Showe, L.C. Genomics 16, 262–263 (1993).

    Article  CAS  Google Scholar 

  6. Dalal, M.A. et al. Neurology 56, 1749–1751 (2001).

    Article  CAS  Google Scholar 

  7. Crocker, A. et al. Neurology 65, 1184–1188 (2005).

    Article  CAS  Google Scholar 

  8. Blouin, A.M. et al. Neurology 65, 1189–1192 (2005).

    Article  CAS  Google Scholar 

  9. Hagan, J.J. et al. Proc. Natl. Acad. Sci. USA 96, 10911–10916 (1999).

    Article  CAS  Google Scholar 

  10. Peyron, C. et al. Nat. Med. 6, 991–997 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Vyse, T. Narcolepsy and the T-cell receptor. Nat Genet 41, 640–641 (2009).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing