Narcolepsy and the T-cell receptor

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The etiology of the sleep disorder narcolepsy has not been firmly established, although an autoimmune pathogenesis has been proposed and is supported by a strong genetic association with the HLA. A new genome-wide association study provides further support for the autoimmune basis of narcolepsy by uncovering a robust association at the T-cell receptor alpha locus.

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Figure 1: Sketch illustrating typical clinical features of narcolepsy: acute onset sleep in the setting of multiple environmental stimuli.

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