Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Genetics of reproductive lifespan

Five genome-wide association studies of the timing of menarche and menopause have now taken us beyond the range of candidate gene and linkage studies. The list of new genetic associations identified for these two traits should shed light on the mechanisms of ovarian aging, as well as breast cancer and other diseases associated with reproductive lifespan.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Potential health impacts of ovarian aging.


  1. Chumlea, W.C. et al. Pediatrics 111, 110–113 (2003).

    Article  Google Scholar 

  2. Euling, S.Y. et al. Pediatrics 121, S172–S191 (2008).

    Article  Google Scholar 

  3. Parent, A.S. et al. Endocr. Rev. 24, 668–693 (2003).

    Article  Google Scholar 

  4. Remsberg, K.E. et al. J. Clin. Endocrinol. Metab. 90, 2718–2724 (2005).

    Article  CAS  Google Scholar 

  5. Sowers, M.R. in Women and Health (eds. Goldman, M.B. & Hatch, M.C.) 1155–1168 (2000).

    Book  Google Scholar 

  6. Van Asselt, K.M. Am. J. Hum. Genet. 74, 444–453 (2004).

    Article  CAS  Google Scholar 

  7. He, C. et al. Nat. Genet. 41, 724–728, (2009).

    Article  CAS  Google Scholar 

  8. Ong, K.K. et al. Nat. Genet. 41, 729–733 (2009).

    Article  CAS  Google Scholar 

  9. Perry, J.R.B. et al. Nat. Genet. 41, 648–650, (2009).

    Article  CAS  Google Scholar 

  10. Sulem, P. et al. Nat. Genet. 41, 734–738 (2009).

    Article  CAS  Google Scholar 

  11. Stolk, L. et al. Nat. Genet. 41, 645–647, (2009).

    Article  CAS  Google Scholar 

  12. Sovio, U. et al. PLoS Genet. 5, e1000409 (2009).

    Article  Google Scholar 

  13. Reeves, G.K. et al. Br. J. Cancer 100, 538–544 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Hartge, P. Genetics of reproductive lifespan. Nat Genet 41, 637–638 (2009).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing