Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The hippocratic finger points the blame at PGE2

Digital clubbing has been recognized since the time of the ancient Greeks as a sign of systemic disease. Now, a new study identifies a role for prostaglandin E2 in the pathogenesis of digital clubbing observed in familial hypertrophic osteoarthropathy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Sarah R. Keilson

References

  1. Uppal, S. et al. Nat. Genet. 40, 789–793 (2008).

    Article  CAS  Google Scholar 

  2. Tai, H.H., Ensor, C.M., Tong, M., Zhou, H. & Yan, F. Prostaglandins Other Lipid Mediat. 68–69, 483–493 (2002).

    Article  Google Scholar 

  3. Cattral, M.S., Altraif, I., Greig, P.D., Blendis, L. & Levy, G.A. Am. J. Med. 97, 369–373 (1994).

    Article  CAS  Google Scholar 

  4. Coggins, K.G. et al. Nat. Med. 8, 91–92 (2002).

    Article  CAS  Google Scholar 

  5. Smith, G.C. Pharmacol. Rev. 50, 35–58 (1998).

    CAS  PubMed  Google Scholar 

  6. Martinez-Lavin, M., Pineda, C., Navarro, C., Buendia, A. & Zabal, C. Pediatr. Cardiol. 14, 181–182 (1993).

    Article  CAS  Google Scholar 

  7. Spicknall, K.E., Zirwas, M.J. & English, J.C., III. J. Am. Acad. Dermatol. 52, 1020–1028 (2005).

    Article  Google Scholar 

  8. Dickinson, C.J. & Martin, J.F. Lancet 2, 1434–1435 (1987).

    Article  CAS  Google Scholar 

  9. Dixey, J. et al. Ann. Rheum. Dis. 47, 218–223 (1988).

    Article  CAS  Google Scholar 

  10. Fox, S.B., Day, C.A. & Gatter, K.C. Lancet 338, 313–314 (1991).

    Article  CAS  Google Scholar 

  11. Atkinson, S. & Fox, S.B. J. Pathol. 203, 721–728 (2004).

    Article  CAS  Google Scholar 

  12. Fabre, J.E. et al. J. Clin. Invest. 107, 603–610 (2001).

    Article  CAS  Google Scholar 

  13. Fatourechi, V., Ahmed, D.D. & Schwartz, K.M. J. Clin. Endocrinol. Metab. 87, 5435–5441 (2002).

    Article  CAS  Google Scholar 

  14. Kitis, G., Thompson, H. & Allan, R.N. BMJ 2, 825–828 (1979).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Coggins, K., Coffman, T. & Koller, B. The hippocratic finger points the blame at PGE2. Nat Genet 40, 691–692 (2008). https://doi.org/10.1038/ng0608-691

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0608-691

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing