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The hippocratic finger points the blame at PGE2

Digital clubbing has been recognized since the time of the ancient Greeks as a sign of systemic disease. Now, a new study identifies a role for prostaglandin E2 in the pathogenesis of digital clubbing observed in familial hypertrophic osteoarthropathy.

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  1. Uppal, S. et al. Nat. Genet. 40, 789–793 (2008).

    Article  CAS  Google Scholar 

  2. Tai, H.H., Ensor, C.M., Tong, M., Zhou, H. & Yan, F. Prostaglandins Other Lipid Mediat. 68–69, 483–493 (2002).

    Article  Google Scholar 

  3. Cattral, M.S., Altraif, I., Greig, P.D., Blendis, L. & Levy, G.A. Am. J. Med. 97, 369–373 (1994).

    Article  CAS  Google Scholar 

  4. Coggins, K.G. et al. Nat. Med. 8, 91–92 (2002).

    Article  CAS  Google Scholar 

  5. Smith, G.C. Pharmacol. Rev. 50, 35–58 (1998).

    CAS  PubMed  Google Scholar 

  6. Martinez-Lavin, M., Pineda, C., Navarro, C., Buendia, A. & Zabal, C. Pediatr. Cardiol. 14, 181–182 (1993).

    Article  CAS  Google Scholar 

  7. Spicknall, K.E., Zirwas, M.J. & English, J.C., III. J. Am. Acad. Dermatol. 52, 1020–1028 (2005).

    Article  Google Scholar 

  8. Dickinson, C.J. & Martin, J.F. Lancet 2, 1434–1435 (1987).

    Article  CAS  Google Scholar 

  9. Dixey, J. et al. Ann. Rheum. Dis. 47, 218–223 (1988).

    Article  CAS  Google Scholar 

  10. Fox, S.B., Day, C.A. & Gatter, K.C. Lancet 338, 313–314 (1991).

    Article  CAS  Google Scholar 

  11. Atkinson, S. & Fox, S.B. J. Pathol. 203, 721–728 (2004).

    Article  CAS  Google Scholar 

  12. Fabre, J.E. et al. J. Clin. Invest. 107, 603–610 (2001).

    Article  CAS  Google Scholar 

  13. Fatourechi, V., Ahmed, D.D. & Schwartz, K.M. J. Clin. Endocrinol. Metab. 87, 5435–5441 (2002).

    Article  CAS  Google Scholar 

  14. Kitis, G., Thompson, H. & Allan, R.N. BMJ 2, 825–828 (1979).

    Article  CAS  Google Scholar 

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Coggins, K., Coffman, T. & Koller, B. The hippocratic finger points the blame at PGE2. Nat Genet 40, 691–692 (2008).

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