Digital clubbing has been recognized since the time of the ancient Greeks as a sign of systemic disease. Now, a new study identifies a role for prostaglandin E2 in the pathogenesis of digital clubbing observed in familial hypertrophic osteoarthropathy.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Pachydermoperiostosis (Touraine–Solente–Gole syndrome): a case report
Journal of Medical Case Reports Open Access 21 February 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Uppal, S. et al. Nat. Genet. 40, 789–793 (2008).
Tai, H.H., Ensor, C.M., Tong, M., Zhou, H. & Yan, F. Prostaglandins Other Lipid Mediat. 68–69, 483–493 (2002).
Cattral, M.S., Altraif, I., Greig, P.D., Blendis, L. & Levy, G.A. Am. J. Med. 97, 369–373 (1994).
Coggins, K.G. et al. Nat. Med. 8, 91–92 (2002).
Smith, G.C. Pharmacol. Rev. 50, 35–58 (1998).
Martinez-Lavin, M., Pineda, C., Navarro, C., Buendia, A. & Zabal, C. Pediatr. Cardiol. 14, 181–182 (1993).
Spicknall, K.E., Zirwas, M.J. & English, J.C., III. J. Am. Acad. Dermatol. 52, 1020–1028 (2005).
Dickinson, C.J. & Martin, J.F. Lancet 2, 1434–1435 (1987).
Dixey, J. et al. Ann. Rheum. Dis. 47, 218–223 (1988).
Fox, S.B., Day, C.A. & Gatter, K.C. Lancet 338, 313–314 (1991).
Atkinson, S. & Fox, S.B. J. Pathol. 203, 721–728 (2004).
Fabre, J.E. et al. J. Clin. Invest. 107, 603–610 (2001).
Fatourechi, V., Ahmed, D.D. & Schwartz, K.M. J. Clin. Endocrinol. Metab. 87, 5435–5441 (2002).
Kitis, G., Thompson, H. & Allan, R.N. BMJ 2, 825–828 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Coggins, K., Coffman, T. & Koller, B. The hippocratic finger points the blame at PGE2. Nat Genet 40, 691–692 (2008). https://doi.org/10.1038/ng0608-691
Issue Date:
DOI: https://doi.org/10.1038/ng0608-691
This article is cited by
-
Pachydermoperiostosis (Touraine–Solente–Gole syndrome): a case report
Journal of Medical Case Reports (2019)
-
HPGD mutations cause cranioosteoarthropathy but not autosomal dominant digital clubbing
European Journal of Human Genetics (2009)