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Molecular screening for new fusion genes in cancer

Gene fusions arising from translocations make an important contribution to the development of cancer. A new study uses high-throughput sequencing to characterize such fusions at an unprecedented level of resolution.

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Figure 1: The wise but blindfolded men could not agree on a description of the elephant's phenotype.

Kim Caesar

References

  1. Campbell, P.J. et al. Nat. Genet. 40, 722–729 (2008).

    Article  CAS  Google Scholar 

  2. Ng, P. et al. Nat. Methods 2, 105–111 (2005).

    Article  CAS  Google Scholar 

  3. Korbel, J.O. et al. Science 318, 420–426 (2007).

    Article  CAS  Google Scholar 

  4. Chen, W. et al. Genome Res. advance online publication, 10.1101/gr.076166.108 (7 March 2008).

  5. Ruan, Y. et al. Genome Res. 17, 828–838 (2007).

    Article  CAS  Google Scholar 

  6. Tomlins, S.A. et al. Science 310, 644–648 (2005).

    Article  CAS  Google Scholar 

  7. Rikova, K. et al. Cell 131, 1190–1204 (2007).

    Article  CAS  Google Scholar 

  8. Soda, M. et al. Nature 448, 561–566 (2007).

    Article  CAS  Google Scholar 

  9. Mitelman, F. et al. Nat. Rev. Cancer 7, 233–245 (2007).

    Article  CAS  Google Scholar 

  10. Heim, S. & Mitelman, F., eds. Cancer Cytogenetics, 3rd Ed. (Wiley, Hoboken, NJ, in the press).

  11. Druker, B.J. Adv. Cancer Res. 91, 1–30 (2004).

    Article  CAS  Google Scholar 

  12. Heim, S. Genes Chromosom. Cancer 5, 188–196 (1992).

    Article  CAS  Google Scholar 

  13. Wood, L.D. et al. Science 318, 1108–1113 (2007).

    Article  CAS  Google Scholar 

  14. Pinkel, D. & Albertson, D.G. Nat. Genet. 37, S11–S17 (2005).

    Article  CAS  Google Scholar 

  15. Hall, P.A. & Lemoine, N.R. J. Pathol. 164, 283–284 (1991).

    Article  CAS  Google Scholar 

Download references

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Heim, S., Mitelman, F. Molecular screening for new fusion genes in cancer. Nat Genet 40, 685–686 (2008). https://doi.org/10.1038/ng0608-685

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