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'Unleashed' natural killers hinder HIV

Nature Genetics volume 39, pages 708–710 (2007)Cite this article

A new study reports that specific combinations of killer immunoglobulin-like receptor and HLA-B alleles influence AIDS progression and plasma HIV RNA levels in HIV-infected individuals. These results suggest that natural killer cells have an important role in recognizing and limiting HIV infection.

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Figure 1: Model of KIR3DL1 and KIR3DS1 interactions with HLA-B Bw4-80I expressed on HIV-uninfected and HIV-infected cells.

Kim Caesar

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Authors and Affiliations

  1. Marcus Altfeld is at Partners AIDS Research Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.,

    Marcus Altfeld

  2. Philip Goulder is at Partners AIDS Research Center and at the Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK. Philip.Goulder@paediatrics.ox.ac.uk,

    Philip Goulder

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  1. Marcus Altfeld
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  2. Philip Goulder
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Altfeld, M., Goulder, P. 'Unleashed' natural killers hinder HIV. Nat Genet 39, 708–710 (2007). https://doi.org/10.1038/ng0607-708

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