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Ribonucleotide reductase and mitochondrial DNA synthesis

The p53-inducible small subunit of ribonucleotide reductase (p53R2) was originally assumed to be involved in DNA repair. A new study finds mutations in the gene encoding p53R2 (RRM2B) in individuals with severe mitochondrial DNA depletion in muscle, demonstrating its central role in mitochondrial DNA synthesis.

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Figure 1: De novo synthesis of deoxyribonucleotides in a mammalian S-phase cell (left) and a nonproliferating Go/G1 cell (right).

Kim Caesar

References

  1. Nordlund, P. & Reichard, P. Annu. Rev. Biochem. 75, 681–706 (2006).

    Article  CAS  Google Scholar 

  2. Chabes, A.L., Pfleger, C.M., Kirschner, M.W. & Thelander, L. Proc. Natl. Acad. Sci. USA 100, 3925–3929 (2003).

    Article  CAS  Google Scholar 

  3. Tanaka, H. et al. Nature 404, 42–49 (2000).

    Article  CAS  Google Scholar 

  4. Nakano, K., Bálint, É., Ashcroft, M. & Vousden, K.H. Oncogene 19, 4283–4289 (2000).

    Article  CAS  Google Scholar 

  5. Kimura, T. et al. Nat. Genet. 34, 440–445 (2003).

    Article  CAS  Google Scholar 

  6. Powell, D.R. et al. Pediatr. Nephrol. 20, 432–440 (2005).

    Article  Google Scholar 

  7. Bourdon, A. et al. Nat. Genet. 39, 776–780 (2007).

    Article  CAS  Google Scholar 

  8. Håkansson, P., Hofer, A. & Thelander, L. J. Biol. Chem. 281, 7834–7841 (2006).

    Article  Google Scholar 

  9. Pontarin, G., Gallinaro, L., Ferraro, P., Reichard, P. & Bianchi, V. Proc. Natl. Acad. Sci. USA 100, 12159–12164 (2003).

    Article  CAS  Google Scholar 

  10. Mandel, H. et al. Nat. Genet. 29, 337–341 (2001).

    Article  CAS  Google Scholar 

  11. Saada, A. et al. Nat. Genet. 29, 342–344 (2001).

    Article  CAS  Google Scholar 

  12. Guittet, O. et al. J. Biol. Chem. 276, 40647–40651 (2001).

    Article  CAS  Google Scholar 

  13. Pontarin, G. et al. J. Biol. Chem. 282, published online 7 April 2007 (doi:10.1074/jbc.M701310200).

    Article  CAS  Google Scholar 

  14. Engström, Y. & Rozell, B. EMBO J. 7, 1615–1620 (1988).

    Article  Google Scholar 

  15. Chabes, A. et al. Cell 112, 391–401 (2003).

    Article  CAS  Google Scholar 

Download references

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Thelander, L. Ribonucleotide reductase and mitochondrial DNA synthesis. Nat Genet 39, 703–704 (2007). https://doi.org/10.1038/ng0607-703

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