The process of gene expression is inherently stochastic and leads to differences in protein abundance from one cell to another. A new study shows that this protein noise is unexpectedly predictable, providing important new insights into the properties and origins of variability in gene expression.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Increasing the efficiency of bacterial transcription simulations: When to exclude the genome without loss of accuracy
BMC Bioinformatics Open Access 12 September 2008
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Rao C.V., Wolf D.M. & Arkin A.P. Nature 420, 231–237 (2002).
Kaern M., Elston T.C., Blake W.J. & Collins J.J. Nat. Rev. Genet. 6, 451–464 (2005).
Raser, J.M. & O'Shea, E.K. Science 309, 2010–2013 (2005).
Bar-Even, A. et al. Nat. Genet. 38, 636–643 (2006).
Blake, W.J., Kaern, M., Cantor, C.R. & Collins, J.J. Nature 422, 633–637 (2003).
Colman-Lerner, A. et al. Nature 437, 699–706 (2005).
Becskei, A., Kaufmann, B.B. & van Oudenaarden, A. Nat. Genet. 37, 937–944 (2005).
Raser, J.M. & O'Shea, E.K. Science 304, 1811–1814 (2004).
Volfson, D. et al. Nature 439, 861–864 (2006).
Fraser, H.B., Hirsh, A.E., Giaever, G., Kumm, J. & Eisen, M.B. PLoS Biol. 2, e137 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Baetz, K., Kærn, M. Predictable trends in protein noise. Nat Genet 38, 610–611 (2006). https://doi.org/10.1038/ng0606-610
Issue Date:
DOI: https://doi.org/10.1038/ng0606-610
This article is cited by
-
Rapid adaptation: a new dimension for evolutionary perspectives in ecology
Population Ecology (2010)
-
Increasing the efficiency of bacterial transcription simulations: When to exclude the genome without loss of accuracy
BMC Bioinformatics (2008)