The identification of hundreds of thousands of clusters of transcriptional start sites, many located within internal exons of protein-coding genes, indicates that promoter sites are common and that transcriptional organization is complex. This transcriptional architecture implies that most genomic regions serve multiple functions.
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Gingeras, T. The multitasking genome. Nat Genet 38, 608–609 (2006). https://doi.org/10.1038/ng0606-608
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DOI: https://doi.org/10.1038/ng0606-608
