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The multitasking genome

The identification of hundreds of thousands of clusters of transcriptional start sites, many located within internal exons of protein-coding genes, indicates that promoter sites are common and that transcriptional organization is complex. This transcriptional architecture implies that most genomic regions serve multiple functions.

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Figure 1: The conventional view of the genome is that protein-coding regions of the genome have few elements that serve more than one function (exon, intron, promoter, enhancer regions).


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Gingeras, T. The multitasking genome. Nat Genet 38, 608–609 (2006).

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