Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Agnosticism and equity in genome-wide association studies

Two new studies evaluate the extent to which widely used SNP platforms capture common variation in different populations, and they present strategies for improving power in whole-genome association studies using fixed marker sets. Their results suggest that genome-wide association studies are finally ready to move from theory to practice.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Cohen, D., Chumakov, I. & Weissenbach, J. Nature 366, 698–701 (1993).

    Article  CAS  Google Scholar 

  2. Lander, E.S. et al. Nature 409, 860–921 (2001).

    Article  CAS  Google Scholar 

  3. Venter, J.C. et al. Science 291, 1304–1351 (2001).

    CAS  PubMed  Google Scholar 

  4. Sachidanandam, R. et al. Nature 409, 928–933 (2001).

    Article  CAS  Google Scholar 

  5. Hinds, D.A. et al. Science 307, 1072–1079 (2005).

    Article  CAS  Google Scholar 

  6. Altshuler, D. et al. Nature 437, 1299–1320 (2005).

    Article  Google Scholar 

  7. Risch, N. & Merikangas, K. Science 273, 1516–1517 (1996).

    Article  CAS  Google Scholar 

  8. Carlson, C.S. et al. Am. J. Hum. Genet. 74, 106–120 (2004).

    Article  CAS  Google Scholar 

  9. de Bakker, P.I. et al. Nat. Genet. 37, 1217–1223 (2005).

    Article  CAS  Google Scholar 

  10. Ke, X. & Cardon, L.R. Bioinformatics 19, 287–288 (2003).

    Article  CAS  Google Scholar 

  11. Barrett, J.C. & Cardon, L.R. Nat. Genet. 38, 659–662 (2006).

    Article  CAS  Google Scholar 

  12. Pe'er, I. et al. Nat. Genet. 38, 663–667 (2006).

    Article  CAS  Google Scholar 

  13. Matsuzaki, H. et al. Nat. Methods 1, 109–111 (2004).

    Article  CAS  Google Scholar 

  14. Steemers, F.J. et al. Nat. Methods 3, 31–33 (2006).

    Article  CAS  Google Scholar 

  15. Gunderson, K.L., Steemers, F.J., Lee, G., Mendoza, L.G. & Chee, M.S. Nat. Genet. 37, 549–554 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carlson, C. Agnosticism and equity in genome-wide association studies. Nat Genet 38, 605–606 (2006). https://doi.org/10.1038/ng0606-605

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0606-605

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing