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Methylation matters: a new spin on maspin

Nature Genetics volume 31, pages 123124 (2002) | Download Citation

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The theory that DNA methylation controls tissue-specific gene expression has remained controversial despite being frequently cited for more than 25 years. A new study shows a pristine example of methylation and gene expression that is cell-type–restricted, although questions about causality persist.

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Author information

Affiliations

  1. Brain Tumor Research Center, Department of Neurological Surgery and UCSF Comprehensive Cancer Center, University of California, San Francisco, California, USA. jcostello@cc.ucsf.edu

    • Joseph F. Costello
  2. Department of Radiation Oncology and the Winship Cancer Institute, Emory University, Atlanta, Georgia, USA. pvertin@emory.edu

    • Paula M. Vertino

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DOI

https://doi.org/10.1038/ng0602-123

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