Wedding genetics with genomics, two groups1,2,3 have independently identified in mammals a multigene family encoding seven-transmembrane proteins that probably represent the hitherto elusive taste receptors. Functional expression in heterologous cells confers responsiveness to bitter tastants in several cases. This discovery may lead to the design of bitter antagonists—and perhaps better butter for Betty Botter.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Adler, E. et al. Cell 100, 693–702 (2000).
Chandrashekar, J. et al. Cell 100, 703–711 (2000).
Matsunami, H., Montmayeur, J.P. & Buck, L.B. Nature 404, 601–604 (2000).
Lindemann, B. Physiol. Rev. 76, 718–766 (1996).
Wong, G.T., Gannon, K.S. & Margolskee, R.F. Nature 381, 796–800 (1996).
Chaudhari, N., Landin, A.M. & Roper, S.D. Nature Neurosci. 3, 113–119 (2000).
Hoon, M.A. et al. Cell 96, 541–551 (1999).
Reed, D.R. et al. Am. J. Hum. Genet. 64, 1478–1480 (1999).
Capeless, C.G. et al. Behav. Genet. 22, 655–663 (1992).
Lush, I.E. et al. Genet. Res. 66, 167–174 (1995).
Rodriguez, I., Feinstein, P. & Mombaerts, P. Cell 97, 199–208 (1999).
Mombaerts, P. Science 286, 707–711 (1999).
Buck, L.B. Cell 100, 611–618 (2000).
Bargmann, C.I. & Kaplan, J.M. Annu. Rev. Neurosci. 21, 279–308 (1998).
Troemel, E.R., Kimmel, B.E. & Bargmann, C.I. Cell 91, 161–169 (1997).
DuLac, C. Neuron 22, 204–206 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mombaerts, P. Better taste through chemistry. Nat Genet 25, 130–132 (2000). https://doi.org/10.1038/75952
Issue Date:
DOI: https://doi.org/10.1038/75952
This article is cited by
-
Genes and ligands for odorant, vomeronasal and taste receptors
Nature Reviews Neuroscience (2004)