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Genetic analysis of ageing: role of oxidative damage and environmental stresses

Nature Genetics volume 13, pages 25–34 (1996)Cite this article

Abstract

Evolutionary theory predicts substantial interspecific and intraspecific differences in the proximal mechanisms of ageing. Our goal here is to seek evidence for common (‘public’) mechanisms among diverse organisms amenable to genetic analysis. Oxidative damage is a candidate for such a public mechanism of ageing. Long-lived strains are relatively resistant to different environmental stresses. The extent to which these stresses produce oxidative damage remains to be established.

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Authors and Affiliations

  1. Departments of Pathology and Genetics, University of Washington, 1959 NE Pacific Street, HSB-K543, Box 357470, Seattle, Washington, 98195-7470, USA

    George M. Martin

  2. Department of Biological Sciences, University of Idaho, Moscow, Idaho, 83843, USA

    Steven N. Austad

  3. Institute for Behavioral Genetics, University of Colorado at Boulder, Box 447, Boulder, Colorado, 80309, USA

    Thomas E. Johnson

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Martin, G., Austad, S. & Johnson, T. Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nat Genet 13, 25–34 (1996). https://doi.org/10.1038/ng0596-25

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