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Fanconi anemia and breast cancer susceptibility meet again

A new study reports biallelic mutations in RAD51C in a Fanconi anemia–like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk. These findings strengthen the link between Fanconi anemia and breast cancer–associated pathways.

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Figure 1: Schematic representation of the FA protein complex and FA-BRCA DNA repair pathway.

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Correspondence to Ephrat Levy-Lahad.

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Levy-Lahad, E. Fanconi anemia and breast cancer susceptibility meet again. Nat Genet 42, 368–369 (2010). https://doi.org/10.1038/ng0510-368

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