Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Chipping away at the genetics of smoking behavior

Three large consortia present comprehensive analyses that identify genetic factors influencing smoking initiation, intensity and cessation. The genetic architecture of these three phases of smoking behavior appears to be largely distinct.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Smoking behavior as a multistep process with genetic influences.

References

  1. Li, M.D. Curr. Psychiatry Rep. 8, 158–164 (2006).

    Article  CAS  Google Scholar 

  2. Thorgeirsson, T.E. et al. Nat. Genet. 42, 448–453 (2010).

    Article  CAS  Google Scholar 

  3. Liu, J.Z. et al. Nat. Genet. 42, 436–440 (2010).

    Article  CAS  Google Scholar 

  4. TAG Consortium. Nat. Genet. 42, 441–447 (2010).

  5. Fanous, S., Hammer, R.P. Jr. & Nikulina, E.M. Neuroscience published online, doi:10.1016/j.neuroscience.2010.02.064 (3 March 2010).

  6. Cazorla, M. et al. PLoS ONE. 5, e9777 (2010).

    Article  Google Scholar 

  7. Vink, J.M. et al. Am. J. Hum. Genet. 84, 367–379 (2009).

    Article  CAS  Google Scholar 

  8. Bierut, L.J. et al. Hum. Mol. Genet. 16, 24–35 (2007).

    Article  CAS  Google Scholar 

  9. Meyer, E.L., Yoshikami, D. & McIntosh, J.M. J. Neurochem. 105, 1761–1769 (2008).

    Article  CAS  Google Scholar 

  10. Klink, R., de Kerchove, d'Exaerde A., Zoli, M. & Changeux, J.P. J. Neurosci. 21, 1452–1463 (2001).

    Article  CAS  Google Scholar 

  11. Swan, G.E. et al. Pharmacogenet. Genomics 15, 115–125 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christopher I Amos.

Ethics declarations

Competing interests

P. Cinciripini has received grant support from Pfizer, which manufactures vrenicline (Chantrix).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Amos, C., Spitz, M. & Cinciripini, P. Chipping away at the genetics of smoking behavior. Nat Genet 42, 366–368 (2010). https://doi.org/10.1038/ng0510-366

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0510-366

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing