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Of flaky tails and itchy skin

Nature Genetics volume 41, pages 512–513 (2009)Cite this article

A new study defines the flaky tail mouse as a model for human atopic dermatitis caused by a null mutation in the gene encoding filaggrin, a key component of the epidermal barrier. Research in these mice will help explain how a disrupted barrier contributes to the pathogenesis of atopic dermatitis and to asthma arising in the context of atopic skin disease.

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Figure 1: Phenotypic heterogeneity in atopic dermatitis.

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Authors and Affiliations

  1. Donata Vercelli is at the Arizona Initiative for the Biology of Complex Diseases (ABCD) and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA. donata@arc.arizona.edu,

    Donata Vercelli

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  1. Donata Vercelli
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Vercelli, D. Of flaky tails and itchy skin. Nat Genet 41, 512–513 (2009). https://doi.org/10.1038/ng0509-512

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