A new study defines the flaky tail mouse as a model for human atopic dermatitis caused by a null mutation in the gene encoding filaggrin, a key component of the epidermal barrier. Research in these mice will help explain how a disrupted barrier contributes to the pathogenesis of atopic dermatitis and to asthma arising in the context of atopic skin disease.
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Vercelli, D. Of flaky tails and itchy skin. Nat Genet 41, 512–513 (2009). https://doi.org/10.1038/ng0509-512
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DOI: https://doi.org/10.1038/ng0509-512
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