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TMPRSS2-ERG and PTEN loss in prostate cancer

Two studies show that the common recurrent gene fusion between TMPRSS2 and ERG promotes prostate cancer in both mouse and humans when PTEN is concurrently lost. In human prostate cancer, the presence of both these aberrations may be indicative of poor prognosis, suggesting that preclinical therapeutic research should target both of these pathways.

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Figure 1: A path to prostate cancer progression.


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Squire, J. TMPRSS2-ERG and PTEN loss in prostate cancer. Nat Genet 41, 509–510 (2009).

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