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TMPRSS2-ERG and PTEN loss in prostate cancer

Nature Genetics volume 41, pages 509–510 (2009)Cite this article

Two studies show that the common recurrent gene fusion between TMPRSS2 and ERG promotes prostate cancer in both mouse and humans when PTEN is concurrently lost. In human prostate cancer, the presence of both these aberrations may be indicative of poor prognosis, suggesting that preclinical therapeutic research should target both of these pathways.

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Figure 1: A path to prostate cancer progression.

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Authors and Affiliations

  1. Jeremy A. Squire is in the Department of Pathology and Molecular Medicine and the NCIC Clinical Trials Group at Queen's University, Kingston, Ontario, Canada. squirej@queensu.ca,

    Jeremy A Squire

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  1. Jeremy A Squire
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Squire, J. TMPRSS2-ERG and PTEN loss in prostate cancer. Nat Genet 41, 509–510 (2009). https://doi.org/10.1038/ng0509-509

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