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From gene expression to disease risk

Gene expression can be an indicator of cellular state, and studies characterizing variation in gene expression have been useful on the cellular level. Two new studies now provide the first direct demonstration of the successful use of the multidimensionality of gene expression to dissect the genetic architecture of complex diseases.

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Figure 1: Genetic basis of disease-related quantitative traits.


  1. Dixon, A.L. et al. Nat. Genet. 39, 1202–1207 (2007).

    Article  CAS  Google Scholar 

  2. Monks, S.A. et al. Am. J. Hum. Genet. 75, 1094–1105 (2004).

    Article  CAS  Google Scholar 

  3. Morley, M. et al. Nature 430, 743–747 (2004).

    Article  CAS  Google Scholar 

  4. Stranger, B.E. et al. Science 315, 848–853 (2007).

    Article  CAS  Google Scholar 

  5. Stranger, B.E. et al. Nat. Genet. 39, 1217–1224 (2007).

    Article  CAS  Google Scholar 

  6. Goring, H.H. et al. Nat. Genet. 39, 1208–1216 (2007).

    Article  Google Scholar 

  7. Moffatt, M.F. et al. Nature 448, 470–473 (2007).

    Article  CAS  Google Scholar 

  8. Chen, Y. et al. Nature 452, 429–435 (2008).

    Article  CAS  Google Scholar 

  9. Emilsson, V. et al. Nature 452, 423–428 (2008).

    Article  CAS  Google Scholar 

  10. Austin, C.P. et al. Nat. Genet. 36, 921–924 (2004).

    Article  CAS  Google Scholar 

  11. Cohen, J.C. et al. Science 305, 869–872 (2004).

    Article  CAS  Google Scholar 

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Dermitzakis, E. From gene expression to disease risk. Nat Genet 40, 492–493 (2008).

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