Gene expression can be an indicator of cellular state, and studies characterizing variation in gene expression have been useful on the cellular level. Two new studies now provide the first direct demonstration of the successful use of the multidimensionality of gene expression to dissect the genetic architecture of complex diseases.
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Dixon, A.L. et al. Nat. Genet. 39, 1202–1207 (2007).
Monks, S.A. et al. Am. J. Hum. Genet. 75, 1094–1105 (2004).
Morley, M. et al. Nature 430, 743–747 (2004).
Stranger, B.E. et al. Science 315, 848–853 (2007).
Stranger, B.E. et al. Nat. Genet. 39, 1217–1224 (2007).
Goring, H.H. et al. Nat. Genet. 39, 1208–1216 (2007).
Moffatt, M.F. et al. Nature 448, 470–473 (2007).
Chen, Y. et al. Nature 452, 429–435 (2008).
Emilsson, V. et al. Nature 452, 423–428 (2008).
Austin, C.P. et al. Nat. Genet. 36, 921–924 (2004).
Cohen, J.C. et al. Science 305, 869–872 (2004).
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Dermitzakis, E. From gene expression to disease risk. Nat Genet 40, 492–493 (2008). https://doi.org/10.1038/ng0508-492
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