Sizing up human height variation

Genome-wide association studies have identified many variants affecting susceptibility to disease. Now, three studies use this approach to study adult height variation in a combined sample size of 63,000 individuals and report a total of 54 validated variants influencing this trait.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Statistical power of detection in GWAS for variants that explain 0.1–0.5% of the variation at a type I error rate of 5 × 10−7 (calculated using the Genetic Power Calculator15).

References

  1. 1

    Fisher, R.A. Trans. Roy. Soc. Edin. 52, 399–433 (1918).

    Article  Google Scholar 

  2. 2

    Galton, F. Nature 33, 295–298 (1886).

    Article  Google Scholar 

  3. 3

    Weedon, M.N. et al. Nat. Genet. 40, 575–583 (2008).

    CAS  Article  Google Scholar 

  4. 4

    Lettre, G. et al. Nat. Genet. 40, 584–591 (2008).

    CAS  Article  Google Scholar 

  5. 5

    Gudbjartsson, D.F. et al. Nat. Genet. 40, 609–615 (2008).

    CAS  Article  Google Scholar 

  6. 6

    Gunnell, D. et al. Epidemiol. Rev. 23, 313–342 (2001).

    CAS  Article  Google Scholar 

  7. 7

    Visscher, P.M., Hill, W.G. & Wray, N.R. Nat. Rev. Genet. 9, 255–266 (2008).

    CAS  Article  Google Scholar 

  8. 8

    The International HapMap Consortium. Nature 437, 1299–1320 (2005).

  9. 9

    The Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).

  10. 10

    Sanna, S. et al. Nat. Genet. 40, 198–203 (2008).

    CAS  Article  Google Scholar 

  11. 11

    Weedon, M.N. et al. Nat. Genet. 39, 1245–1250 (2007).

    CAS  Article  Google Scholar 

  12. 12

    Easton, D.F. et al. Am. J. Hum. Genet. 81, 873–883 (2007).

    CAS  Article  Google Scholar 

  13. 13

    Rebbeck, T.R., Spitz, M. & Wu, X. Nat. Rev. Genet. 5, 589–597 (2004).

    CAS  Article  Google Scholar 

  14. 14

    Wray, N.R., Goddard, M.E. & Visscher, P.M. Genome Res. 17, 1520–1528 (2007).

    CAS  Article  Google Scholar 

  15. 15

    Purcell, S., Cherny, S.S. & Sham, P.C. Bioinformatics 19, 149–150 (2003).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Visscher, P. Sizing up human height variation. Nat Genet 40, 489–490 (2008). https://doi.org/10.1038/ng0508-489

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing