New studies indicate that damage to the mitochondrial genome (mtDNA) accumulates with age, specifically in the dopaminergic neurons of the substantia nigra implicated in Parkinson disease. These findings suggest that mtDNA damage is important in the decay of dopaminergic neurons in aging and in Parkinson disease, resulting in loss of mitochondrial function and, ultimately, neuronal death.
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Katie Ris
References
Kraytsberg, Y. et al. Nat. Genet. 38, 518–520 (2006).
Bender, A. et al. Nat. Genet. 38, 515–517 (2006).
Attardi, G. & Schatz, G. Annu. Rev. Cell Biol. 4, 289–333 (1988).
Dimauro, S. & Davidzon, G. Ann. Med. 37, 222–232 (2005).
Srivastava, S. & Moraes, C.T. Hum. Mol. Genet. 14, 893–902 (2005).
Corral-Debrinski, M. et al. Nat. Genet. 2, 324–329 (1992).
Rossignol, R. et al. Biochem. J. 370, 751–762 (2003).
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Manfredi, G. mtDNA clock runs out for dopaminergic neurons. Nat Genet 38, 507–508 (2006). https://doi.org/10.1038/ng0506-507
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DOI: https://doi.org/10.1038/ng0506-507
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