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Epigenetics of hypertension in pregnancy

Maternal hypertension in pregnancy is a genetically complex condition originating in the placenta. Because of imprinting, only the maternal copy of the gene encoding STOX1 is expressed in invasive placental extravillous trophoblasts. Therefore, maternally inherited missense mutations affecting this putative DNA-binding protein predispose to preeclampsia, possibly by interfering with differentiation of the trophoblast cells.

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Figure 1: Matrilineal inheritance of STOX1 missense mutations in a pedigree with preeclampsia.

Katie Ris

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Arngrímsson, R. Epigenetics of hypertension in pregnancy. Nat Genet 37, 460–461 (2005). https://doi.org/10.1038/ng0505-460

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