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Linking cilia to Wnts

Nature Genetics volume 37, pages 455–457 (2005)Cite this article

Inversin is a component of a poorly understood cilia-based mechanism responsible for specifying the left-right axis during development and for maintaining normal kidney architecture throughout life. A new study now suggests that inversin might act as a flow-regulated molecular switch between canonical and noncanonical Wnt pathways, providing insights into the mechanisms underlying cilia-based signaling processes.

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Figure 1: Flow-based model of Wnt regulation in the kidney.

Katie Ris

Figure 2: Noncanonical Wnt signaling and tubular morphogenesis.

Katie Ris

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  1. the Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA

    Gregory G Germino

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  1. Gregory G Germino
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Germino, G. Linking cilia to Wnts. Nat Genet 37, 455–457 (2005). https://doi.org/10.1038/ng0505-455

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