News & Views | Published:

Triglycerides and toggling the tummy

Subjects

Multiple mechanisms regulate adipose mass and body weight. In addition to factors controlling appetite and energy expenditure, mechanisms controlling adipocyte number, triglyceride synthesis and triglyceride breakdown have important functions. But recent studies challenge our concepts concerning each of these.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Smith, S.J. et al. Nature Genet. 25, 87– 90 (2000).

  2. 2

    Flier, J.S. & Maratos-Flier, E. Cell 92, 437–440 (1998).

  3. 3

    Friedman, J.M. & Halaas, J.L. Nature 395, 763–770 (1998).

  4. 4

    Hagan, M.M. et al. J. Neurosci. 19, 2362– 2367 (1999).

  5. 5

    Zhang, Y. et al. Nature 372, 425–432 (1994).

  6. 6

    Montague, C.T. et al. Nature 387, 903–908 (1997).

  7. 7

    Lee, G.H. et al. Nature 379, 632–635 (1996).

  8. 8

    Marsh, D.J. et al. Nature Genet. 21, 119– 122 (1999).

  9. 9

    Shimada, M., Tritos, N.A., Lowell, B.B., Flier, J.S. & Maratos-Flier, E. Nature 396, 670–674 (1998).

  10. 10

    Ricquier, D. & Bouillaud, F. Biochem. J. 345, 161–179 (2000).

  11. 11

    Lowell, B.B. et al. Nature 366, 740–742 (1993).

  12. 12

    Enerback, S. et al. Nature 387, 90–93 (1997).

  13. 13

    Argyropoulos, G. et al. J. Clin. Invest. 102, 1345– 1351 (1998).

  14. 14

    Wu, Z., Puigserver, P. & Spiegelman, B.M. Curr. Opin. Cell. Biol. 11, 689–694 (1999).

  15. 15

    Shimomura, I. et al. Genes Dev. 12, 3182– 3194 (1998).

  16. 16

    Gavrilova, O., Marcus-Samuels, B., Leon, L.R., Vinson, C. & Reitman, M.L. Nature 403, 850–851 (2000).

  17. 17

    Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W. & Kahn, C.R. N. Engl. J. Med. 339, 953–959 (1998).

  18. 18

    Beamer, B.A. et al. Diabetes 47, 1806– 1808 (1998).

  19. 19

    Osuga, J. et al. Proc. Natl Acad. Sci. USA. 97, 787– 792 (2000).

Download references

Author information

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.

About this article

Publication history

  • Issue Date

DOI

https://doi.org/10.1038/75610

Further reading

Figure 1: Increasing complexity in the regulation of body weight and adipose tissue mass.
Figure 2: Pathways of triglyceride synthesis.